|
KMID : 0370220160600040211
|
|
Yakhak Hoeji
2016 Volume.60 No. 4 p.211 ~ p.221
|
|
|
Effect of Growth Hormone Therapy on Height in Children and Adolescents
|
|
Cheong Eun-Jin
Chun Pu-Soon
|
|
|
Abstract
|
|
|
|
Growth hormone (GH) is widely used to treat growth disorders in patients with either GH deficiency (GHD) or non-GHD. However, the effects of GH therapy are inconsistent. The aim of this study was to investigate the effect of growth hormone therapy on height in children and adolescents in South Korea. A retrospective clinical analysis was conducted using the electronic medical records of the subjects who started GH therapy between January 2013 and December 2014 at a teaching hospital located in Seoul, Korea. In order to evaluate the effect of GH therapy, the auxological parameters such as height, height standard deviation scores (SDS), and height velocity was analyzed according to the duration of treatment and baseline height SDS. A total of 428 subjects were analyzed. GH therapy improved height SDS in the subjects treated for no more than 1 year as well as more than 1 year (0.27 vs. 0.68, p=0.006). Height SDS gain was significantly greater in the subjects with lower height SDS than the subjects with higher one at baseline (1.22 for SDS < -2 vs. -2 ≤ SDS < 0, p < 0.001; 1.23 for -2 ≤ SDS < 0 vs. 0 ≤ SDS, p < 0.001). Negative correlations were found between increase in height SDS after treatment and both baseline age and height SDS (r=-0.33 for age; r=-0.38 for height SDS, both p < 0.001).
|
|
|
KEYWORD
|
|
|
growth hormone, children, adolescent, height growth
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|